Heybach J P, Boyle P C
Physiol Behav. 1982 Dec;29(6):1171-3. doi: 10.1016/0031-9384(82)90315-8.
Separate groups of rats were chronically fed diets adulterated with either bitter tasting quinine sulfate (QSO4), equal amounts of quinine in the less bitter form of quinine tannate (QT), or an amount of sucrose octaacetate (SOA) determined to have aversive taste properties equal to the QSO4 diet. Dietary adulteration with SOA did not affect food intake or body weight. Dietary adulteration with quinine resulted in an initial reduction in food intake that showed a relative recovery but remained depressed compared to the intake of a group eating a quinine-free diet. Ingestion of diets containing equal amounts of quinine base resulted in equivalent chronic body weight reductions, despite different aversive diet characteristics. These results suggest that bitter taste is not the significant variable underlying the body weight effects of quinine but that quinine exerts some postingestive effect on body weight mediated by a slight but sustained decrease in the level of energy intake.
将大鼠分成不同组，长期喂食掺有苦味硫酸奎宁（QSO4）、等量苦味较轻的鞣酸奎宁（QT）形式的奎宁或经测定具有与含QSO4饮食相同厌恶味道特性的蔗糖八乙酸酯（SOA）的日粮。用SOA掺假日粮不影响食物摄入量或体重。用奎宁掺假日粮导致食物摄入量最初减少，虽显示出相对恢复，但与食用不含奎宁日粮组的摄入量相比仍较低。摄入含等量奎宁碱的日粮导致慢性体重下降程度相当，尽管日粮的厌恶特性不同。这些结果表明，苦味不是奎宁对体重影响的重要变量，而是奎宁通过能量摄入水平轻微但持续的降低对体重产生某种食后效应。
