糖尿病和非糖尿病大鼠基底膜合成的体内研究。

In vivo studies on basement membrane synthesis in diabetic and nondiabetic rats.

作者信息

Hasslacher C, Kopischke H G, Bürklin E, Gechter F, Reichenbacher R

出版信息

Res Exp Med (Berl). 1982;181(3):245-51. doi: 10.1007/BF01851197.

Abstract

In rats with chronic diabetes, the synthesis of glomerular basement membrane was investigated in vivo by injection of 3H-proline. Compared to the nondiabetic controls, the basement membrane synthesis was markedly raised. The formation of hydroxyproline as parameter for the synthesis of the collagen portion of the basement membrane increased to a somewhat greater extent than the incorporation of 3H-proline. Hydroxyproline formation and proline incorporation showed a close correlation with the blood sugar level in the diabetic rats.

摘要

在患有慢性糖尿病的大鼠中，通过注射³H - 脯氨酸在体内研究肾小球基底膜的合成。与非糖尿病对照组相比，基底膜合成显著增加。作为基底膜胶原部分合成参数的羟脯氨酸形成，其增加程度略大于³H - 脯氨酸的掺入。羟脯氨酸形成和脯氨酸掺入与糖尿病大鼠的血糖水平密切相关。