Miserocchi G, Mariani E, Negrini D
Respir Physiol. 1982 Dec;50(3):381-92. doi: 10.1016/0034-5687(82)90030-5.
Supraphrenic and subphrenic liquid pressures in supine dogs and rabbits were found to be about 2 cm H2O more negative than costal and mediastinal liquid pressures at the same lung height. Peritoneal liquid pressure was negative at all lung heights in dogs and slightly positive below 25% of lung height in rabbits. The vertical gradients of liquid pressure did not differ significantly in either species between the pleural and peritoneal cavities and were lower than 1 cm H2O/cm. From the peritoneal protein concentration (2.3 and 3.5 g/100 ml in dogs and rabbits, respectively) we calculated a filtration pressure for the peritoneal mesothelium and a lymphatic role was hypothesized to explain negative liquid pressures in the peritoneal cavity. The greater negativity of the subphrenic as compared with the peritoneal data could be related to a strong respiratory-dependent lymphatic action. A similar mechanism and/or a low filtration conductance of the diaphragmatic pleura may explain the costo-supraphrenic liquid pressure difference. The present results, extending previously published data on the mediastinal side of the lung, further support the existence of local differences in fluid dynamics in the pleural cavity.
研究发现，仰卧位犬和兔的膈上及膈下液体压力比相同肺高度处的肋部和纵隔液体压力约低2 cmH₂O。犬在所有肺高度时腹膜液体压力均为负值，兔在低于肺高度25%时腹膜液体压力略为正值。胸膜腔和腹膜腔之间的液体压力垂直梯度在两种动物中均无显著差异，且低于1 cmH₂O/cm。根据腹膜蛋白浓度（犬和兔分别为2.3和3.5 g/100 ml），我们计算了腹膜间皮的滤过压力，并推测存在淋巴作用以解释腹膜腔内的负液体压力。与腹膜数据相比，膈下液体压力的更大负值可能与强烈的呼吸依赖性淋巴作用有关。类似的机制和/或膈胸膜的低滤过传导性可能解释肋膈上液体压力差异。本研究结果扩展了先前发表的关于肺纵隔侧的数据，进一步支持了胸膜腔内液体动力学存在局部差异的观点。
