Miserocchi G, Pistolesi M, Miniati M, Bellina C R, Negrini D, Giuntini C
J Appl Physiol Respir Environ Exerc Physiol. 1984 Feb;56(2):526-32. doi: 10.1152/jappl.1984.56.2.526.
In supine anesthetized dogs we measured pleural liquid pressure (Pliq) in mediastinal, diaphragmatic, apical, and costal regions at different lung heights during eupneic breathing. At end expiration and at a given height, Pliq was similar in the costal and apical regions, but it was lower in the diaphragmatic and mediastinal compartments. Inspiratory swings toward lower values were progressively greater with increasing height and moving from costal to apical, diaphragmatic and mediastinal compartments. Thus during inspiration, at any height, the costomediastinal and costodiaphragmatic Pliq difference increased while a costoapical difference developed. One minute after injection of 0.5-1 ml of saline at different points within the cavity, end-expiratory liquid pressure became higher on the average by 0.45, 1.55, and 0.55 cmH2O in the apical, mediastinal, and diaphragmatic compartments, respectively, while no change was observed on costal side. These results suggested liquid accumulation in the compartments displaying a lower Pliq. This was confirmed by following, with a gamma camera, on a frontal projection of the lung, the intrapleural distribution of a bolus containing 99mTc-labeled albumin injected at various places.
在仰卧麻醉的犬中，我们在平静呼吸时测量了不同肺高度下纵隔、膈、尖和肋区的胸液压力（Pliq）。在呼气末且在给定高度时，肋区和尖区的Pliq相似，但在膈区和纵隔区较低。随着高度增加以及从肋区向尖区、膈区和纵隔区移动，吸气时向更低值的波动逐渐增大。因此在吸气时，在任何高度，肋纵隔和肋膈的Pliq差值增加，同时出现肋尖差值。在胸腔内不同点注射0.5 - 1 ml盐水1分钟后，呼气末液体压力在尖区、纵隔区和膈区平均分别升高0.45、1.55和0.55 cmH₂O，而肋侧未观察到变化。这些结果提示液体在显示较低Pliq的区域积聚。通过γ相机在肺的正位投影上追踪在不同部位注射含99mTc标记白蛋白的团注后的胸膜内分布，证实了这一点。
