Gozukirmizi E, Meyer J S, Okabe T, Amano T, Mortel K, Karacan I
Sleep. 1982;5(4):329-42. doi: 10.1093/sleep/5.4.329.
Cerebral blood flow (CBF) measurements were combined with sleep polysomnography in nine patients with complex partial seizures. Two methods were used: the 133Xe method for measuring regional (rCBF) and the stable xenon CT method for local (LCBF). Compared to nonepileptic subjects, who show diffuse CBF decreases during stages I-II, non-REM sleep onset, patients with complex partial seizures show statistically significant increases in CBF which are maximal in regions where the EEG focus is localized and are predominantly seen in one temporal region but are also propagated to other cerebral areas. Both CBF methods gave comparable results, but greater statistical significance was achieved by stable xenon CT methodology. CBF increases are more diffuse than predicted by EEG paroxysmal activity recorded from scalp electrodes. An advantage of the 133Xe inhalation method was achievement of reliable data despite movement of the head. This was attributed to the use of a helmet which maintained the probes approximated to the scalp. Disadvantages were poor resolution (7 cm3) and two-dimensional information. The advantage of stable xenon CT method is excellent resolution (80 mm3) in three dimensions, but a disadvantage is that movement of the head in patients with seizure disorders may limit satisfactory measurements.
对9例复杂部分性癫痫患者的脑血流量（CBF）测量与睡眠多导睡眠图进行了联合研究。使用了两种方法：用于测量局部脑血流量（rCBF）的133Xe方法和用于测量局部脑血容量（LCBF）的稳定氙CT方法。与非癫痫受试者相比，非癫痫受试者在非快速眼动睡眠第I-II期（睡眠开始阶段）脑血流量呈弥漫性下降，而复杂部分性癫痫患者的脑血流量在脑电图病灶所在区域有统计学意义的显著增加，且主要见于一个颞叶区域，但也会扩散到其他脑区。两种脑血流量测量方法得出了相似的结果，但稳定氙CT方法具有更高的统计学显著性。脑血流量的增加比头皮电极记录的脑电图阵发性活动所预测的更为弥漫。133Xe吸入法的一个优点是，尽管头部移动仍能获得可靠数据。这归因于使用了一个头盔，使探头保持贴近头皮。缺点是分辨率低（7 cm3）且为二维信息。稳定氙CT方法的优点是三维分辨率极佳（80 mm3），但缺点是癫痫患者头部的移动可能会限制测量的满意度。
