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[狼疮病中的无菌性骨坏死]

[Aseptic bone necrosis in lupus disease].

作者信息

Pilosof T, Andreev T

出版信息

Vutr Boles. 1978;17(5):84-92.

PMID:716375
Abstract

Seven cases with aseptic necrosis in lupus disseminatus are presented being 9.70 per cent of 72 patients with confirmed systemic lupus, observed in the cours of 20 years. Six cases with lupus disseminatus are concerned--acute and subacute paroxysm a course and one case with chronic skin form--discoid lupus, complicated in the course of its evolution with aseptic necrosis of the right head of the femur. The cause for detection of the bone lesions in the cases presented, was the pain, especially manifested with the necrosis localized in the supporting bones of the lower limbs. The analysis of the state of the patients with systemic lupus reveals that all cases, are severe forms of the disease with multiorgan involvement, febrile reactions and the presence of vascular phenomena--Raynaud syndrome, coronary and cerebral arteriitis. High doses of corticosteroid preparations were used in the treatment of the disease due to its lasting progress (paroxysms of 8--12 months).

摘要

本文报告7例播散性狼疮无菌性坏死病例,占72例确诊系统性红斑狼疮患者的9.70%,观察时间为20年。其中6例为播散性狼疮——急性和亚急性发作病程,1例为慢性皮肤型——盘状狼疮,在其演变过程中并发右股骨头无菌性坏死。所报告病例中骨病变的检测原因是疼痛,尤其是下肢承重骨坏死时疼痛尤为明显。对系统性红斑狼疮患者病情的分析表明,所有病例均为疾病的严重形式,有多器官受累、发热反应以及血管现象——雷诺综合征、冠状动脉和脑动脉炎。由于疾病进展持续(发作8 - 12个月),治疗中使用了高剂量的皮质类固醇制剂。

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