Bremmelgaard A, Bygbjerg I, Høiby N
Scand J Infect Dis. 1982;14(4):271-5. doi: 10.3109/inf.1982.14.issue-4.05.
The first case of melioidosis reported in Denmark was in a 64-year-old man 2 weeks after his return from a 3-week visit to Kenya. The clinical course was characterized by septicaemia and Pseudomonas pseudomallei was isolated from repeated blood cultures, urine and sputum. Transient impairment of cellular immunity was observed. During the convalescence a cell-mediated immune response against the pathogen was detected by the lymphocyte blast transformation test. Two precipitins against P. pseudomallei were detected by crossed immunoelectrophoresis; the most pronounced was directed against the common antigen of P. aeruginosa. The patient was treated with a combination of oxytetracycline, sulfamethoxazole and trimethoprim for one month, followed by sulfamethoxazole and trimethoprim for another month. The clinical response to the treatment was good. The patient had previously had recurrent pulmonary tuberculosis. The relationship of melioidosis to tuberculosis is briefly discussed.
丹麦报告的首例类鼻疽病发生在一名64岁男性身上，他在从肯尼亚进行了为期3周的访问返回2周后发病。临床病程以败血症为特征，从多次血培养、尿液和痰液中分离出类鼻疽假单胞菌。观察到细胞免疫出现短暂损害。在康复期间，通过淋巴细胞转化试验检测到针对该病原体的细胞介导免疫反应。通过交叉免疫电泳检测到两种针对类鼻疽假单胞菌的沉淀素；最明显的一种针对铜绿假单胞菌的共同抗原。患者接受了土霉素、磺胺甲恶唑和甲氧苄啶联合治疗1个月，随后又接受了磺胺甲恶唑和甲氧苄啶治疗1个月。治疗的临床反应良好。该患者既往有复发性肺结核病史。本文简要讨论了类鼻疽病与结核病的关系。
