血小板与巨核细胞体积之间的关系。

The relationship between platelet and megakaryocyte volumes.

作者信息

Martin J F, Trowbridge E A, Salmon G L, Slater D N

出版信息

Thromb Res. 1982 Nov 15;28(4):447-59. doi: 10.1016/0049-3848(82)90162-1.

Abstract

Planimetric megakaryocyte and nuclear areas were measured by histological techniques in rabbits subjected to 6 days of thrombocytopenia and in normal steady state function. A theoretical correction factor enables an estimate to be obtained of the actual megakaryocyte, megakaryocyte cytoplasm and nuclear volumes in these two states. The corresponding platelet volumes after 6 days of thrombocytopenia and in normal function were also measured. This enables the number of platelets produced by a single megakaryocyte (on average) to be computed directly in the two states of platelet production. The experiments showed that the volume of megakaryocyte cytoplasm increased significantly in stimulated platelet production. The number of platelets produced per megakaryocyte doubled and the mean platelet volume also increased during stimulated production. An explanation is given for the observed behaviour of platelet and megakaryocyte volumes.

摘要

采用组织学技术，对经历6天血小板减少症的兔子以及处于正常稳态功能的兔子，测量其平面测量法得出的巨核细胞和细胞核面积。一个理论校正因子能够对这两种状态下实际的巨核细胞、巨核细胞细胞质和细胞核体积进行估计。还测量了血小板减少6天后以及正常功能状态下相应的血小板体积。这使得能够直接计算出在两种血小板生成状态下单个巨核细胞（平均）产生的血小板数量。实验表明，在刺激血小板生成过程中，巨核细胞细胞质体积显著增加。在刺激生成过程中，每个巨核细胞产生的血小板数量翻倍，平均血小板体积也增加。文中对观察到的血小板和巨核细胞体积的行为给出了解释。