Belleville J, Freyria A M, Pinet A, Cornillon B, Paul J, Clendinnen G, Eloy R
Thromb Res. 1982 Nov 15;28(4):533-44. doi: 10.1016/0049-3848(82)90169-4.
The platelet function was investigated in 65 patients submitted to diagnostic excretion urography (injection of 60 ml contrast medium). Blood sampling was performed before (T0) 90 seconds after (T1) and 30 minutes after (T2) injection of the radiocontrast molecule (RCM). Five RCM of different osmolality ionicity and nature of the lateral chain have been tested. Platelet aggregation, platelet release of ATP, osmolality, total calcemia and ionized calcium level were determined on each plasma sample as well as RCM concentration at T1 and T2. Decrease (20 - 40%) of platelet aggregation occurred at T1, whichever platelet aggregating agent (ADP, collagen, Ristocetin or thrombin) were used (significant after Iopamidol 300 and Na Meg Ioxaglate). Platelet release of ATP induced by collagen was also decreased or delayed. These changes were rapidly reversible and a tendency to improvement was observed at T2. Among the five RCM tested, one (Na Diatrizoate) might be a proaggregating agent. No changes of osmolality occurred in the plasma and no correlation could be established between RCM concentration and platelet inhibition. A pathogenic hypothesis is suggested by the significant fall of total and ionized calcium level after RCM injection.
对65例接受诊断性排泄性尿路造影（注射60ml造影剂）的患者进行了血小板功能研究。在注射放射性造影剂（RCM）前（T0）、注射后90秒（T1）和30分钟（T2）采集血样。测试了五种不同渗透压、离子性和侧链性质的RCM。测定每个血浆样本的血小板聚集、ATP的血小板释放、渗透压、总钙血症和离子钙水平以及T1和T2时的RCM浓度。无论使用何种血小板聚集剂（ADP、胶原、瑞斯托霉素或凝血酶），在T1时血小板聚集均下降（20 - 40%）（碘帕醇300和碘克沙酸钠镁后有显著差异）。胶原诱导的ATP的血小板释放也减少或延迟。这些变化迅速可逆，且在T2时观察到有改善趋势。在所测试的五种RCM中，一种（泛影酸钠）可能是促聚集剂。血浆渗透压无变化，且RCM浓度与血小板抑制之间未建立相关性。RCM注射后总钙和离子钙水平显著下降提示了一种致病假说。
