Stefanov G, Tishkov I, Todorova L
Vutr Boles. 1982;21(5):53-8.
The authors share their results from the studies on the incidence and characteristic of hypertonic syndrome in 132 patients with chronic glomerulonephritis (ChGN). In that random group, 65.1 per cent had renoparenchymal hypertension (RPH), 34.8 per cent of the patients had RPH among the patients with normal renal function, and with various degrees of chronic renal insufficiency (ChRI) - 95.4 per cent. In 69 patients, the diagnosis was confirmed by puncture biopsy, with a predomination of membranous, membranous-proliferative, IgA and endoproliferative ChGN. With the exception of IgA nephritis, RPH in the rest is found relatively often even in the absence of ChRI. The symptomatics of RPH was relatively poor--most frequently the patients complained of headache--in 48 per cent but patients with ChGN without RPH also had the same complaints--26 per cent. Complaints as dizziness, tinnitus and insomnia were rare. The hypertension was with a short duration (according to anamnestic data)--in 2/3 less than three years and 40 per cent of the patients had hypertonic crises or/and acute left cardiac insufficiency in spite of the relatively little alterations in ECG and fundus of the eye. Those were mainly patients with advanced ChRI. The authors lay stress upon the necessity of complex treatment of renal insufficiency and of hypertension with a view to the improvement of the prognosis of those patients.
作者分享了对132例慢性肾小球肾炎(ChGN)患者高渗综合征发病率及特征的研究结果。在该随机分组中,65.1%的患者患有肾实质高血压(RPH),肾功能正常的患者中34.8%患有RPH,而在不同程度慢性肾功能不全(ChRI)的患者中这一比例为95.4%。69例患者经穿刺活检确诊,以膜性、膜增生性、IgA及内皮增生性ChGN为主。除IgA肾病外,即使没有ChRI,其余类型中RPH也相对常见。RPH的症状相对不典型——最常见的是患者主诉头痛——占48%,但无RPH的ChGN患者也有同样主诉——占26%。头晕、耳鸣及失眠等主诉较少见。高血压病程较短(根据既往病史)——2/3的患者病程不到三年,40%的患者尽管心电图和眼底改变相对较小,但仍发生高血压危象或/和急性左心功能不全。这些主要是ChRI晚期患者。作者强调为改善这些患者的预后,对肾功能不全和高血压进行综合治疗的必要性。