[Pharmacokinetics of antibiotics and sulfanilamides in pregnancy and labor].

Pharmacokinetic parameters may be influenced by pregnancy and labour. A number of antibiotics and chemotherapeutics were studied by the authors who found reduction of fictitious initial concentration as well as increase of both volume of distribution and total clearance. Elimination half-life was found to be prolonged with significance only in women in labour (ampicillin). Studies into drug concentrations and their metabolites did not provide any evidence to change of biotransformation in gravidity. Doses of antimicrobially acting chemopharmaceuticals in gravidity should be close to upper limits.