Edwards E K, Horwitz S N, Frost P
Arch Dermatol Res. 1982;272(3-4):263-7. doi: 10.1007/BF00509055.
The effect of three nonsteroidal antiinflammatory agents (NSAIA) on ultraviolet B (UV-B)-induced erythema was studied in normal human volunteers. Aspirin, indomethacin, and ibuprofen were administered orally 2 h before exposure to UV-B from fluorescent sunlamps and at 4-h intervals for a total of four doses. The minimal dose of light to produce erythema (MED) was determined for each subject with and without drugs. There was a 240% increase in the mean MED when the NSAIA were given. NSAIA, given orally, can increase the threshold for UV-B-induced erythema when administered near the time of irradiation.
在正常人类志愿者中研究了三种非甾体抗炎药（NSAIA）对紫外线B（UV-B）诱导的红斑的影响。在暴露于荧光太阳灯的UV-B之前2小时口服阿司匹林、吲哚美辛和布洛芬，并每隔4小时给药一次，共给药四次。在有药和无药的情况下，为每个受试者确定产生红斑的最小光照剂量（MED）。服用NSAIA时，平均MED增加了240%。口服NSAIA在照射时间附近给药时，可提高UV-B诱导红斑的阈值。
