Mahrle G
Arch Dermatol Res. 1982;274(1-2):93-9. doi: 10.1007/BF00510363.
To investigate the turnover of complete junctional membrane areas ("domain turnover"), psoriatic epidermis, keratoacanthoma, and squamous cell carcinoma were studied with an electron microscope and compared with the normal epidermis. Three types of domain turnover of junctions were observed. First, the uptake of intact intercellular junctions, which occurred as complete or incomplete annular junctions in the cytoplasm. Mainly gap junctions were involved. Second, the formation of autojunctions bridging an infolding at the surface of a cell, which is then incorporated and occurs partly with an attached saccule in the cytoplasm. This type was confined to desmosomes. Finally, the loss of intercellular desmosomes into the intercellular space was observed. Proliferating epidermis was associated with an increased domain turnover of gap junctional membrane areas. Domain turnover of desmosomes prevailed in tumors.
为研究完整连接膜区域的更新（“结构域更新”），利用电子显微镜对银屑病表皮、角化棘皮瘤和鳞状细胞癌进行了研究，并与正常表皮进行了比较。观察到连接的三种结构域更新类型。第一，完整细胞间连接的摄取，其在细胞质中以完整或不完整的环状连接形式出现。主要涉及缝隙连接。第二，自连接的形成，其跨越细胞表面的内褶，然后被并入，部分与细胞质中附着的囊泡一起出现。这种类型仅限于桥粒。最后，观察到细胞间桥粒丢失到细胞间隙中。增殖性表皮与缝隙连接膜区域的结构域更新增加有关。桥粒的结构域更新在肿瘤中占主导地位。
