Skerrow C J
Department of Dermatology, University of Glasgow, Scotland.
Invest Cell Pathol. 1978 Jan-Mar;1(1):23-37.
The differentiation of epidermal keratinocytes is accompanied by a regular sequence of changes in the nature of their adhesive interactions. The basis of these changes is discussed with reference to the more detailed studies of intercellular adhesion of other tissue types. In the early stages, desmosome formation predominates. A sequence of molecular events which may underlie desmosome formation and junctional stability is constructed. At the later stages of differentiation, adhesive interactions between non-junctional membranes are of increasing importance, and cells undergo pronounced flattening. The involvement of the cytoskeleton in these processes is considered. Possibilities for further studies on keratinocyte adhesion in normal and pathological epidermis are suggested.
表皮角质形成细胞的分化伴随着其黏附相互作用性质的一系列有规律的变化。参照对其他组织类型细胞间黏附的更详细研究，讨论了这些变化的基础。在早期阶段，桥粒形成占主导。构建了一系列可能构成桥粒形成和连接稳定性基础的分子事件。在分化后期，非连接膜之间的黏附相互作用变得越来越重要，细胞会显著扁平化。考虑了细胞骨架在这些过程中的作用。提出了对正常和病理表皮中角质形成细胞黏附进行进一步研究的可能性。
