梗阻性黄疸大鼠对血管活性药物的心血管反应性
Cardiovascular responsiveness to vasoactive agents in rats with obstructive jaundice.
作者信息
Finberg J P, Seidman R, Better O S
出版信息
Clin Exp Pharmacol Physiol. 1982 Nov-Dec;9(6):639-43. doi: 10.1111/j.1440-1681.1982.tb00835.x.
Abstract
- Pressor responses to tyramine, beta-phenylethylamine and angiotensin II were normal in urethane-anaesthetized rats 7 days after division of the common bile duct. The pressor response to noradrenaline was enhanced at the highest dose level used. 2. The hypotensive response to haemorrhage was exaggerated in bile duct divided rats. 3. The exaggerated haemorrhagic hypotension of bile duct divided rats is unlikely to be the result of impaired vascular response to noradrenaline or angiotensin II, or of accumulation of false neurotransmitters by sympathetic nerves.
摘要
- 在胆总管结扎7天后的乌拉坦麻醉大鼠中，对酪胺、β-苯乙胺和血管紧张素II的升压反应正常。在所使用的最高剂量水平下，对去甲肾上腺素的升压反应增强。2. 胆总管结扎大鼠对出血的降压反应增强。3. 胆总管结扎大鼠出血性低血压增强不太可能是血管对去甲肾上腺素或血管紧张素II反应受损，或交感神经积累假神经递质的结果。
Zotero 插件