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梗阻性黄疸大鼠对血管活性药物的心血管反应性

Cardiovascular responsiveness to vasoactive agents in rats with obstructive jaundice.

作者信息

Finberg J P, Seidman R, Better O S

出版信息

Clin Exp Pharmacol Physiol. 1982 Nov-Dec;9(6):639-43. doi: 10.1111/j.1440-1681.1982.tb00835.x.

DOI:10.1111/j.1440-1681.1982.tb00835.x
PMID:7166008
Abstract
  1. Pressor responses to tyramine, beta-phenylethylamine and angiotensin II were normal in urethane-anaesthetized rats 7 days after division of the common bile duct. The pressor response to noradrenaline was enhanced at the highest dose level used. 2. The hypotensive response to haemorrhage was exaggerated in bile duct divided rats. 3. The exaggerated haemorrhagic hypotension of bile duct divided rats is unlikely to be the result of impaired vascular response to noradrenaline or angiotensin II, or of accumulation of false neurotransmitters by sympathetic nerves.
摘要
  1. 在胆总管结扎7天后的乌拉坦麻醉大鼠中,对酪胺、β-苯乙胺和血管紧张素II的升压反应正常。在所使用的最高剂量水平下,对去甲肾上腺素的升压反应增强。2. 胆总管结扎大鼠对出血的降压反应增强。3. 胆总管结扎大鼠出血性低血压增强不太可能是血管对去甲肾上腺素或血管紧张素II反应受损,或交感神经积累假神经递质的结果。

相似文献

1
Cardiovascular responsiveness to vasoactive agents in rats with obstructive jaundice.梗阻性黄疸大鼠对血管活性药物的心血管反应性
Clin Exp Pharmacol Physiol. 1982 Nov-Dec;9(6):639-43. doi: 10.1111/j.1440-1681.1982.tb00835.x.
2
Pressor and mesenteric arterial hyporesponsiveness to angiotensin II is an early event in haemorrhagic hypotension in anaesthetised rats.在麻醉大鼠失血性低血压过程中,压力感受器和肠系膜动脉对血管紧张素II的反应性降低是早期事件。
Cardiovasc Res. 1999 Oct;44(1):166-75. doi: 10.1016/s0008-6363(99)00194-7.
3
Systemic hypotension and pressor responsiveness in cholestasis. A study in conscious 3-day bile duct ligated rats.胆汁淤积时的全身性低血压和升压反应性。对清醒的3日龄胆管结扎大鼠的一项研究。
J Hepatol. 1990 Jul;11(1):70-6. doi: 10.1016/0168-8278(90)90274-u.
4
Blunted pressor response to angiotensin and sympathomimetic amines in bile-duct ligated dogs.胆管结扎犬对血管紧张素和拟交感胺的升压反应减弱。
Clin Sci (Lond). 1981 Nov;61(5):535-9. doi: 10.1042/cs0610535.
5
Anesthesia and pressor responsiveness in chronic bile-duct-ligated dogs.慢性胆管结扎犬的麻醉与升压反应性
Hepatology. 1990 Apr;11(4):551-6. doi: 10.1002/hep.1840110405.
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Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine.α2-肾上腺素能受体激动剂B-HT 933对麻醉性出血大鼠的升压作用:与去氧肾上腺素血流动力学效应的比较
Br J Pharmacol. 1989 Jun;97(2):419-32. doi: 10.1111/j.1476-5381.1989.tb11969.x.
7
Responses of mean arterial pressure to pressor agents and diuretics in renal hypertensive and salt hypertensive rats.肾性高血压大鼠和盐性高血压大鼠平均动脉压对升压药和利尿剂的反应。
Br J Pharmacol. 1971 Jun;42(2):179-92. doi: 10.1111/j.1476-5381.1971.tb07099.x.
8
[Studies on the mechanism of the pressor effect of mineralocorticoids. I. Influence of 9 alpha-fluorohydrocortisone on the pressor effect of tyramine, noradrenaline, and angiotensin, on blood volume, and on plasma renin concentration (author's transl)].
Klin Wochenschr. 1973 Nov 15;51(22):1091-7. doi: 10.1007/BF01468302.
9
Cardiovascular and catecholamine responses to acute haemorrhage in anaesthetized potassium-adapted rats.麻醉状态下钾适应大鼠对急性出血的心血管和儿茶酚胺反应
Res Exp Med (Berl). 1993;193(3):175-85. doi: 10.1007/BF02576225.
10
The effect of corticotrophin (ACTH) administration on the pressor action of angiotensin II, noradrenaline and tyramine in sheep.促肾上腺皮质激素(ACTH)给药对绵羊体内血管紧张素II、去甲肾上腺素和酪胺升压作用的影响。
Clin Exp Pharmacol Physiol. 1978 Sep-Oct;5(5):449-55. doi: 10.1111/j.1440-1681.1978.tb00696.x.

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Br J Pharmacol. 2000 Aug;130(7):1457-67. doi: 10.1038/sj.bjp.0703471.