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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Finberg J P, Syrop H A, Better O S

Clin Sci (Lond). 1981 Nov;61(5):535-9. doi: 10.1042/cs0610535.

The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine and beta-phenylethylamine were examined before and after bile-duct ligation in conscious trained dogs. 2. The pressor response to angiotensin II was markedly suppressed after bile-duct ligation, although responses to noradrenaline and the indirectly acting sympathomimetic amines were only slightly reduced. 3. Bradycardia, in response to the pressor drugs, and tachycardia, in response to isoprenaline, were unchanged after bile-duct ligation. 4. Refractoriness to the pressor action of angiotensin after chronic bile-duct ligation in the present study is similar to that reported previously by others in patients with liver cirrhosis. 5. No evidence was found in the bile-duct ligated dog to support a role of false neurotransmitters as mediators of the circulatory disturbances associated with liver injury.

在有意识的经训练犬的胆管结扎前后，检测了其对血管紧张素II、去甲肾上腺素、异丙肾上腺素、酪胺和β-苯乙胺的升压及心率反应。2. 胆管结扎后，对血管紧张素II的升压反应明显受到抑制，而对去甲肾上腺素和间接作用的拟交感胺的反应仅略有降低。3. 胆管结扎后，对升压药的心动过缓和对异丙肾上腺素的心动过速均无变化。4. 本研究中慢性胆管结扎后对血管紧张素升压作用的耐受性与其他人先前报道的肝硬化患者相似。5. 在胆管结扎犬中未发现证据支持假性神经递质作为与肝损伤相关的循环紊乱介质的作用。

Finberg J P, Syrop H A, Better O S

Clin Sci (Lond). 1981 Nov;61(5):535-9. doi: 10.1042/cs0610535.

The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine and beta-phenylethylamine were examined before and after bile-duct ligation in conscious trained dogs. 2. The pressor response to angiotensin II was markedly suppressed after bile-duct ligation, although responses to noradrenaline and the indirectly acting sympathomimetic amines were only slightly reduced. 3. Bradycardia, in response to the pressor drugs, and tachycardia, in response to isoprenaline, were unchanged after bile-duct ligation. 4. Refractoriness to the pressor action of angiotensin after chronic bile-duct ligation in the present study is similar to that reported previously by others in patients with liver cirrhosis. 5. No evidence was found in the bile-duct ligated dog to support a role of false neurotransmitters as mediators of the circulatory disturbances associated with liver injury.

在有意识的经训练犬的胆管结扎前后，检测了其对血管紧张素II、去甲肾上腺素、异丙肾上腺素、酪胺和β-苯乙胺的升压及心率反应。2. 胆管结扎后，对血管紧张素II的升压反应明显受到抑制，而对去甲肾上腺素和间接作用的拟交感胺的反应仅略有降低。3. 胆管结扎后，对升压药的心动过缓和对异丙肾上腺素的心动过速均无变化。4. 本研究中慢性胆管结扎后对血管紧张素升压作用的耐受性与其他人先前报道的肝硬化患者相似。5. 在胆管结扎犬中未发现证据支持假性神经递质作为与肝损伤相关的循环紊乱介质的作用。