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连续测定癌胚抗原以早期检测复发性胃癌。

Serial determinations of carcinoembryonic antigen for early detection of recurrent gastric cancer.

作者信息

Tamada R, Hiramoto Y, Abe Y, Nouzuka T, Okamura T, Masuda H, Kano T, Kumashiro R, Inokuchi K

出版信息

Jpn J Surg. 1982;12(6):429-33. doi: 10.1007/BF02469833.

DOI:10.1007/BF02469833
PMID:7166914
Abstract

In attempts to predict the recurrence of gastric cancer, postoperative changes in serum carcinoembryonic antigen (CEA) levels are monitored in our clinic by radioimmunoassay (Dainabot, Japan). Recurrences are suspected when serum CEA levels are 4 ng/ml, in the postoperative period. Out of 34 patients in whom there were increases in serum CEA, 18 were confirmed to have a recurrence and 15 of these 18 patients were assessed accurately by serial postoperative levels of CEA, two patients died of a recurrence after elevation of serum CEA levels. Thus, recurrence was predicted in 17 out of 34 patients (50 per cent) and in 12 out of 17 patients there was a metastasis to the liver. In 14 out of 34 patients there are no signs of recurrence 9 to 25 months after serum CEA elevations.

摘要

为了预测胃癌的复发情况,我们诊所通过放射免疫分析法(日本戴拿保公司产品)监测血清癌胚抗原(CEA)水平的术后变化。术后血清CEA水平≥4 ng/ml时怀疑有复发。在34例血清CEA升高的患者中,18例被证实复发,其中15例通过术后连续的CEA水平得到准确评估,2例患者在血清CEA水平升高后死于复发。因此,34例患者中有17例(50%)预测有复发,其中12例有肝转移。34例患者中有14例在血清CEA升高后9至25个月无复发迹象。

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Serial determinations of carcinoembryonic antigen for early detection of recurrent gastric cancer.连续测定癌胚抗原以早期检测复发性胃癌。
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引用本文的文献

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Combined evaluation of preoperative serum sialyl-Tn antigen and carcinoembryonic antigen levels is prognostic for gastric cancer patients.术前血清唾液酸-Tn抗原和癌胚抗原水平的联合评估对胃癌患者具有预后价值。
Br J Cancer. 1994 Jan;69(1):163-6. doi: 10.1038/bjc.1994.27.
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Jpn J Surg. 1987 Jul;17(4):269-75. doi: 10.1007/BF02470699.
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本文引用的文献

1
DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.通过免疫耐受和吸收技术证明人类结肠癌中的肿瘤特异性抗原
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Early detection of recurrence of gastric cancer by serial plasma carcinoembryonic antigen assays.通过系列血浆癌胚抗原检测早期发现胃癌复发
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Results of CEA-initiated second-look surgery for recurrent colorectal cancer.癌胚抗原(CEA)引发的复发性结直肠癌二次探查手术的结果。
术前癌胚抗原测定在胃癌中的临床应用价值
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Serum CEA levels facilitate detection of recurrences of cancer in patients after gastrectomy.血清癌胚抗原水平有助于检测胃癌切除术后患者的癌症复发情况。
Jpn J Surg. 1985 Jan;15(1):23-9. doi: 10.1007/BF02469853.
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Late results of postoperative long term cancer chemotherapy for advanced carcinoma of the stomach.进展期胃癌术后长期癌症化疗的远期疗效
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Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma.血浆癌胚抗原在胃肠道、乳腺癌和支气管癌诊断中的作用。
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Carcinoembryonic antigen. Quantitative variations in circulating levels in benign and malignant digestive tract diseases.癌胚抗原。良性和恶性消化道疾病中循环水平的定量变化。
Adv Intern Med. 1974;19:413-33.
7
Role of serial plasma C.E.A. assays in detection of recurrent and metastatic colorectal carcinomas.连续血浆癌胚抗原检测在复发性和转移性结直肠癌检测中的作用。
Br Med J. 1974 Nov 16;4(5941):382-5. doi: 10.1136/bmj.4.5941.382.
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Carcinoembryonic antigen in management of colorectal carcinoma.癌胚抗原在结直肠癌管理中的应用
Br Med J. 1974 Oct 26;4(5938):183-7. doi: 10.1136/bmj.4.5938.183.
9
Detection of recurrence of large-bowel carcinoma by radioimmunoassay of circulating carcinoembryonic antigen (C.E.A.).通过循环癌胚抗原(C.E.A.)放射免疫测定法检测大肠癌复发
Lancet. 1974 Sep 7;2(7880):535-40. doi: 10.1016/s0140-6736(74)91872-8.
10
Prognostic factors in colon carcinoma: correlation of serum carcinoembryonic antigen level and tumor histopathology.结肠癌的预后因素:血清癌胚抗原水平与肿瘤组织病理学的相关性。
Hum Pathol. 1975 Jan;6(1):31-45. doi: 10.1016/s0046-8177(75)80108-0.