The selectivity of the anorectic effect of satietin. II. Ineffectiveness of satietin on the water intake in food deprived rats. Effect of satietin in "conditioned aversion" paradigm.

The effect of satietin, a potent endogenius anorexigenic agent, on the water intake of fed and food deprived rats was studied and compared with the effects of calcitonin. In rats deprived of food for 96 h and supplied with water ad libitum, no change in the water intake of intracerebroventricularly (icvtr) administered satietin (2 units/rat), calcitonin (1 unit/rat) and saline (0.2 ml/rat), respectively, was observed. In animals deprived of food and water for 23 h, satietin (2 units/rat, icvtr) left water consumption unchanged, whereas calcitonin (1 unit/rat, icvtr) inhibited the intake of water significantly. The possible role of an aversive reaction in the anorexigenic effect of satietin was also studied using the "conditioned aversion" paradigm of Garcia et al. [3]. Satietin (250 units/kg, intravenously) did not elicit aversion for food.