Sándor G, Knoll J
Physiol Behav. 1985 May;34(5):851-3. doi: 10.1016/0031-9384(85)90390-7.
The influence of anorectic doses of satietin, calcitonin, fenfluramine and amphetamine on the amount of food eaten, on the time elapsed before taking the first tablet (latency) and on the time-structure of food intake during a one hour feeding session, divided into four 15-minute periods, was measured in rats after one day starvation with a pellet-detecting eatometer. In contrast to fenfluramine, amphetamine significantly increased the time elapsed before taking the first tablet, indicating the stimulation of a satiety mechanism by fenfluramine and the inhibition of a feeding mechanism by amphetamine. In this test satietin and calcitonin acted like fenfluramine. The time-course of food intake was significantly different in the amphetamine and fenfluramine-treated animals, the latter ate more during the first 15-minute period. Satietin and calcitonin acted like fenfluramine in this test, too. The results are consistent with the view that satietin acts by activating a satiety mechanism.
使用颗粒检测式进食计，在饥饿一天的大鼠中测量了食欲抑制剂剂量的饱腹感素、降钙素、芬氟拉明和苯丙胺对进食量、服用第一片食物前经过的时间（潜伏期）以及在一小时进食时段内（分为四个15分钟时段）食物摄入的时间结构的影响。与芬氟拉明不同，苯丙胺显著增加了服用第一片食物前经过的时间，这表明芬氟拉明刺激了饱腹感机制，而苯丙胺抑制了进食机制。在该试验中，饱腹感素和降钙素的作用与芬氟拉明类似。苯丙胺和芬氟拉明处理的动物的食物摄入时间进程显著不同，后者在第一个15分钟时段进食更多。饱腹感素和降钙素在该试验中的作用也与芬氟拉明类似。这些结果与饱腹感素通过激活饱腹感机制起作用的观点一致。
