Knoll B, Knoll J
Pol J Pharmacol Pharm. 1982;34(1-3):17-23.
Satietin, a potent endogenous anorectic substance separated from human serum, plays a role of a rate limiting satiety signal in the negative feed back of food intake. The selectivity of satietin on some behavioral tests (unconditioned avoidance reaction, one-way as well as two-way conditioning, open field, consolidated conditioned reflex) was checked and compared to calcitonin. TRH and Glp-Leu-Pro-OH. Satietin seemed to be ineffective on all but one (open field) behavioral tests. Calcitonin and Glp-Leu-Pro-OH increased open field activity. Results indicate that satietin is an endogenous anorectic substance with a peculiar selectivity.
饱腹感素是一种从人血清中分离出的强效内源性厌食物质，在食物摄入的负反馈中起限速饱腹感信号的作用。检测了饱腹感素在一些行为测试（非条件回避反应、单向和双向条件反射、旷场试验、巩固条件反射）中的选择性，并与降钙素、促甲状腺激素释放激素和甘丙素进行了比较。饱腹感素似乎对除一项（旷场试验）行为测试外的所有测试均无效果。降钙素和甘丙素增加了旷场试验中的活动。结果表明，饱腹感素是一种具有特殊选择性的内源性厌食物质。
