Vaupel P, Otte J, Manz R
Prog Clin Biol Res. 1982;107:65-74.
Upon heating at 40 degrees C for 30 min, the oxygenation of the tumor tissue significantly improved compared with control conditions at 35 degrees C. In contradistinction to this, the tumor oxygenation significantly decreased directly after 43 degrees C hyperthermia. A further temperature rise to 45 degrees C caused the oxygenation to drop drastically because of a severe restriction of nutritive blood flow. The changes in tumor oxygenation during hyperthermia seem to be predominantly mediated through changes in tumor blood flow, which showed the same directional changes.
在40℃加热30分钟后，与35℃的对照条件相比，肿瘤组织的氧合显著改善。与此相反，43℃热疗后肿瘤氧合立即显著下降。进一步升温至45℃会因营养性血流严重受限导致氧合急剧下降。热疗期间肿瘤氧合的变化似乎主要是由肿瘤血流的变化介导的，肿瘤血流也呈现相同的方向性变化。
