Poser S
Psychiatr Neurol Med Psychol (Leipz). 1982 Dec;34(12):705-11.
In a multicentre study the data of 2057 patients with multiple sclerosis were recorded and analysed in respect to the different courses. The remitting form begins at earlier age with a higher frequency of sensitivity disturbances, optic neuritis and other cranial nerve disturbances whereas the chronic progressive process starts with spastic pareses and sphincter disturbances in a higher percentage of cases. During the further course these differences persist. With the beginning of a chronic progression the prognosis is unfavorable whether the process started with bouts or with progression from onset. 22% of the cases have a benign course (increase of not more than 1 degree of disability during a 5-year-period). In an epidemiological material the percentage of benign cases is at least one third. Except of the above statements the clinical symptomatology could not be correlated to the prognosis.
在一项多中心研究中，记录并分析了2057例多发性硬化症患者的数据，涉及不同病程。缓解型发病年龄较早，感觉障碍、视神经炎和其他颅神经障碍的发生率较高，而慢性进行性病程在更高比例的病例中始于痉挛性轻瘫和括约肌障碍。在后续病程中，这些差异持续存在。随着慢性进展的开始，无论病程始于发作还是起病即为进展性，预后均不佳。22%的病例病程呈良性（5年内残疾程度增加不超过1级）。在一份流行病学资料中，良性病例的比例至少为三分之一。除上述情况外，临床症状与预后无相关性。
