Schoenwolf G C
Scan Electron Microsc. 1982(Pt 1):289-308.
Neurulation consists of a complex series of events that result in formation of the neural tube, the rudiment of the entire adult central nervous system. This article discusses primary neurulation, a process that occurs in three major stages: formation of the neural plate; bending of the neural plate, with formation of the neural groove and neural folds; and fusion of the neural folds, with formation of the roof of the neural tube and overlying surface epithelium. In addition, new information is presented on the morphogenesis of the chick neuroepithelium during bending of the neural plate. These data show that bending of the neural plate occurs in two distinct steps at all craniocaudal levels: elevation of the lateral parts of the neural plate and the incipient neural folds, and formation and convergence of the definitive neural folds. Elevation is associated with the formation of a midline, ventral locus of bending, and convergence, with the formation of bilateral loci of bending on the future luminal sides of the dorsolateral walls of the neural groove. Several mechanisms possibly involved in the stages and steps of primary neurulation are discussed.
神经胚形成包括一系列复杂的事件，这些事件导致神经管的形成，而神经管是整个成体中枢神经系统的原基。本文讨论原发性神经胚形成，这一过程发生在三个主要阶段：神经板的形成；神经板弯曲，形成神经沟和神经褶；神经褶融合，形成神经管顶和覆盖其上的表面上皮。此外，还介绍了有关神经板弯曲过程中鸡神经上皮形态发生的新信息。这些数据表明，神经板在所有头尾水平上的弯曲都分两个不同步骤进行：神经板外侧部分和初期神经褶的抬高，以及确定的神经褶的形成和汇聚。抬高与中线、腹侧弯曲位点的形成有关，而汇聚与神经沟背外侧壁未来管腔侧双侧弯曲位点的形成有关。文中讨论了可能参与原发性神经胚形成各阶段和步骤的几种机制。
