Maisin J R, Van Gorp U, de Saint-Georges L
Scan Electron Microsc. 1982(Pt 1):403-12.
Male mice of the BALB/c strain were exposed at an age of 12-14 weeks, to different doses of X-rays, either to the entire thorax or to the right hemithorax. At various times after exposure mice were sacrificed and the lung was examined by transmission or scanning electron microscopy. Radiation symptoms following exposure to 15-20 Gy can be divided into three phases: Early, from a few hours to a few weeks after exposure, changes in capillary permeability and morphological alterations in all types of lung cells are prominent. At intermediate times, from a few weeks to about 7 months after exposure, the symptoms of radiation pneumonitis arise essentially, as a consequence of the action of radiation on the epithelium of the alveoli, and are characterized by a large increase in size, and probably in number of type II epithelial cells. Scanning electron microscopy brings additional arguments that the lesions in the epithelial cells, mainly of type II, are the principal cause of radiation pneumonitis and that capillary damage probably plays a secondary role.
将12 - 14周龄的BALB/c品系雄性小鼠，暴露于不同剂量的X射线下，照射部位为整个胸部或右半胸。在暴露后的不同时间处死小鼠，通过透射或扫描电子显微镜检查肺部。暴露于15 - 20 Gy后的辐射症状可分为三个阶段：早期，在暴露后数小时至数周内，毛细血管通透性变化和所有类型肺细胞的形态改变较为突出。在中期，即暴露后数周至约7个月，放射性肺炎症状基本出现，这是辐射对肺泡上皮作用的结果，其特征是II型上皮细胞大小大幅增加，数量可能也增加。扫描电子显微镜提供了更多证据，表明主要是II型上皮细胞的损伤是放射性肺炎的主要原因，而毛细血管损伤可能起次要作用。
