Jean-Faucher C, Berger M, de Turckheim M, Veyssiere G, Jean C
Acta Endocrinol (Copenh). 1978 Dec;89(4):780-8. doi: 10.1530/acta.0.0890780.
Male mice were raised in cohabitation with females from birth to 90 days. Testosterone was measured every 10 days in plasma and testes. Sex difference in body weight was related to the pre-pubertal increase of testosterone levels in males. The weight of the seminal vesicle was positively correlated with circulating testosterone levels between 1 and 40 days but not between 50 and 90 days. Testosterone concentrations in the plasma and testes were high at birth: 630 pg/ml and 58.0 +/- 17.7 ng/100 mg; they subsequently decreased during the first days of life and remained low until day 20:240 +/- 110 pg/ml and 0.1 +/- 0.03 ng/100 mg. The testosterone levels then increased rapidly between days 20 and 30 and especially between 30 and 40 reaching their maxima: 5770 +/- 1720 pg/ml and 123.7 +/- 18.3 ng/100 mg testis. This increase was transitory and testosterone levels fell after day 40. By 90 days, the testosterone levels, 440 +/- 65 pg/ml and 43.2 +/- 5.5 ng/100 mg testis, were comparable to those measured at birth. Plasma testosterone and age were positively correlated between 1 and 40 days, and negatively between 50 and 90 days. The first fertile matings occurred at age 40 days.
雄性小鼠从出生到90天与雌性小鼠共同饲养。每10天测量血浆和睾丸中的睾酮水平。体重的性别差异与雄性青春期前睾酮水平的升高有关。精囊重量在1至40天与循环睾酮水平呈正相关，但在50至90天则无相关性。出生时血浆和睾丸中的睾酮浓度很高：分别为630 pg/ml和58.0 +/- 17.7 ng/100 mg；随后在出生后的头几天下降，并在20天前一直保持较低水平：240 +/- 110 pg/ml和0.1 +/- 0.03 ng/100 mg。然后睾酮水平在20至30天之间迅速上升，尤其是在30至40天之间达到最大值：5770 +/- 1720 pg/ml和123.7 +/- 18.3 ng/100 mg睾丸。这种升高是短暂的，40天后睾酮水平下降。到90天时，睾酮水平分别为440 +/- 65 pg/ml和43.2 +/- 5.5 ng/100 mg睾丸，与出生时测量的水平相当。1至40天血浆睾酮与年龄呈正相关，50至90天呈负相关。首次可育交配发生在40天龄时。
