Kusakari J, Kambayashi J, Ise I, Kawamoto K
Acta Otolaryngol. 1978 Nov-Dec;86(5-6):336-41. doi: 10.3109/00016487809107512.
The effect of bumetanide upon the endocochlear potential (EP) was examined in 46 guinea pigs. The EP was reduced with dosages of 5 mg/kg or more. The maximum depression of the EP (reduction to -30 to -40 mV) was obtained at a dosage of 30 mg/kg. The recovery of the potential was incomplete at any dosage within three hours and the response pattern of the EP to bumetanide was similar to that to ethacrynic acid. The present experiments revealed that bumetanide, by weight, has a stronger ototoxic potency than the other "loop" diuretics--furosemide and ethacrynic acid. However, the diuretic effect of 1 mg bumetanide is equivalent to 40 to 60 mg furosemide or ethacrynic acid. Therefore, the relative ototoxic potency of bumetanide is much smaller suggesting that from a clinical standpoint bumetanide is much safer than the other "loop" diuretics.
在46只豚鼠身上研究了布美他尼对内耳电位（EP）的影响。剂量为5mg/kg或更高时，EP降低。在30mg/kg的剂量下，EP出现最大程度的降低（降至-30至-40mV）。在三小时内，任何剂量下电位的恢复均不完全，并且EP对布美他尼的反应模式与对依他尼酸的反应模式相似。目前的实验表明，按重量计算，布美他尼的耳毒性效力比其他“袢”利尿剂——呋塞米和依他尼酸更强。然而，1mg布美他尼的利尿作用相当于40至60mg呋塞米或依他尼酸。因此，布美他尼的相对耳毒性效力要小得多，这表明从临床角度来看，布美他尼比其他“袢”利尿剂安全得多。
