Linari G, Baldieri Linari M, Castellacci R
Boll Soc Ital Biol Sper. 1982 Dec 30;58(24):1655-60.
Gastric secretion was studied in conscious rats with chronic gastric fistulae maintained in restraint cages. Experiments were performed 24 hours after surgical procedure: the stomachs were washed with 3 ml of saline and gastric acid determined by titration of pH 6 every 30 minutes. The i.v. injection of 75 mg/kg of 2DG strongly stimulated gastric secretion, with a 5-fold increase of acid output in comparison to control rats. The slow intravenous injection of dermorphin, 15 min before 2DG, dose-dependently inhibited the stimulant effect of the latter. Opioid activity of dermorphin has been reported (5); on the other hand, the intracerebroventricular injection of opiates has been shown to decrease the gastric secretion of the rat by Rozé et al. (3). The effectiveness of dermorphin given by intravenous route observed in present experiments seems to suggest the hypothesis that dermorphin (and other opiates) may act, besides central, also on peripheral sites.
在置于约束笼中的具有慢性胃瘘的清醒大鼠身上研究胃分泌。在手术操作24小时后进行实验：用3毫升生理盐水冲洗胃，并每30分钟通过滴定至pH 6来测定胃酸。静脉注射75毫克/千克的2-脱氧葡萄糖强烈刺激胃分泌，与对照大鼠相比，酸分泌量增加了5倍。在注射2-脱氧葡萄糖前15分钟缓慢静脉注射德莫啡，剂量依赖性地抑制了后者的刺激作用。德莫啡的阿片样活性已有报道(5)；另一方面，Rozé等人(3)已表明脑室内注射阿片类药物可减少大鼠的胃分泌。在本实验中观察到的静脉途径给予德莫啡的有效性似乎提示了这样一种假说，即德莫啡(以及其他阿片类药物)除了作用于中枢外，也可能作用于外周部位。
