Guglietta A, Irons B J, Lazarus L H
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental and Health Sciences, Research Triangle Park, NC.
Methods Find Exp Clin Pharmacol. 1988 Aug;10(8):481-5.
A comparison of the effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion was assayed in rats two hours after their intracerebroventricular or subcutaneous administration. All three peptides significantly reduced gastric acid output after central administration. The order of potency was: bombesin greater than salmon calcitonin greater than dermorphin. After subcutaneous injection salmon calcitonin was very potent in reducing gastric acid output, while dermorphin was active only at high doses; bombesin had a very weak effect on the same parameter. Time-course studies demonstrated that the effect of these peptides reached a peak 1-2 h after their central administration, followed by a slow recovery toward control values. Salmon calcitonin, however, has a very prolonged action on the gastric parameters studied. These data indicate that bombesin and dermorphin might act centrally to modulate gastric acid secretion in the rat, while the very potent intracerebroventricular and subcutaneous action of salmon calcitonin suggests a different mechanism of action.
在大鼠脑室内或皮下注射蛙皮素、皮啡肽和鲑鱼降钙素两小时后，测定了它们对胃酸分泌的影响。三种肽经中枢给药后均显著降低胃酸分泌量。效力顺序为：蛙皮素＞鲑鱼降钙素＞皮啡肽。皮下注射后，鲑鱼降钙素在降低胃酸分泌量方面非常有效，而皮啡肽仅在高剂量时有活性；蛙皮素对相同参数的作用非常微弱。时程研究表明，这些肽经中枢给药后1 - 2小时作用达到峰值，随后缓慢恢复至对照值。然而，鲑鱼降钙素对所研究的胃参数有非常持久的作用。这些数据表明，蛙皮素和皮啡肽可能通过中枢作用调节大鼠胃酸分泌，而鲑鱼降钙素在脑室内和皮下的强效作用提示其作用机制不同。
