Nørgaard T
Acta Pathol Microbiol Scand A. 1978 Sep;86A(5):427-35. doi: 10.1111/j.1699-0463.1978.tb02067.x.
In salt-depleted and salt-loaded rat kidneys a study was made of the structural segmentation of the proximal convoluted tubule (PCT) and the histochemical activity of non-specific acid and alkaline phosphatases and succinate dehydrogenase in the same segments. No quantitative structural or segmental alterations were observed, but significant changes in enzyme activity occured. These comprised: 1) A decrease in activity of acid phosphatase in segment 1 and the transitional zone in salt-depleted kidneys, and an increase in enzyme activity in segment 2 in salt-loaded kidneys. 2) a decrease in alkaline phosphatase activity in segment 2 in both salt-depleted and salt-loaded kidneys and 3) a decrease in succinate dehydrogenase activity in segment 2 in salt-depleted kidneys, and an increase in activity in the same segment in salt-loaded kidneys. Thus long-term variation in sodium intake are followed by segment-correlated variations in the activity of acid and alkaline phosphatase and succinate dehydrogenase in the PCT.
在盐缺乏和盐负荷的大鼠肾脏中，对近端曲管（PCT）的结构分段以及同一节段中非特异性酸性和碱性磷酸酶及琥珀酸脱氢酶的组织化学活性进行了研究。未观察到定量的结构或节段性改变，但酶活性发生了显著变化。这些变化包括：1）盐缺乏肾脏中第1节段和过渡区酸性磷酸酶活性降低，盐负荷肾脏中第2节段酶活性增加。2）盐缺乏和盐负荷肾脏中第2节段碱性磷酸酶活性均降低。3）盐缺乏肾脏中第2节段琥珀酸脱氢酶活性降低，盐负荷肾脏中同一节段活性增加。因此，钠摄入量的长期变化伴随着近端曲管中酸性和碱性磷酸酶及琥珀酸脱氢酶活性的节段相关变化。
