单次注射后[2,3-¹⁴C]丙烯腈在大鼠体内的分布与蓄积
Distribution and accumulation of [2,3-14C]acrylonitrile in rat after single injection.
作者信息
Sato M, Hirasawa F, Ogata M, Takizawa Y, Kojima H, Yoshida T
出版信息
Ecotoxicol Environ Saf. 1982 Oct;6(5):489-94. doi: 10.1016/0147-6513(82)90030-6.
The distribution and accumulation of acrylonitrile after the single i.p. injection of [2,3-14C]acrylonitrile were examined by whole-body autoradiography and by the determination of 14C radioactivities in several tissues and subcellular fractions after a whole-body perfusion. 14C Radioactivity was seen strongly in blood, particularly in red blood cells, and in several tissues including lung, liver, and kidney. Longer retention of radioactivity in brain and muscle was observed. At the subcellular level a relatively high specific radioactivity was seen in cytosol fractions of the brain, liver, and kidney.
单次腹腔注射[2,3 - 14C]丙烯腈后，通过全身放射自显影以及全身灌注后测定多个组织和亚细胞组分中的14C放射性，研究了丙烯腈的分布和蓄积情况。在血液中，尤其是红细胞中，以及包括肺、肝和肾在内的多个组织中，均可见到强烈的14C放射性。在脑和肌肉中观察到放射性的滞留时间更长。在亚细胞水平上，在脑、肝和肾的胞质溶胶组分中可见相对较高的比放射性。
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