Burri P H, Pfrunder H B, Berger L C
Exp Lung Res. 1982 Dec;4(1):11-28. doi: 10.3109/01902148209039246.
This study describes the morphology of the adaptive response of the pulmonary parenchyma after the resection of lung tissue. Rats aged 23 days were subjected to the bilobectomy of the right upper and middle lobes representing 25% of the total lung volume. On the postoperative Days 1, 4, 6, 9, 12, 18, and 30, the lungs were fixed by standardized intratracheal instillation of fixative, their volume determined by water displacement, and pieces of the left lung prepared for scanning electron microscopy (SEM). Age-matched normal and sham-operated animals served as controls. Lung volumes of operated rats rapidly matched control values. In SEM, the volume gain appeared to be achieved by a widening of the airspaces affecting primarily the alveolar ducts on postoperative Day 1 and shifting later to the alveolar level (Day 4). On Days 4 and 6, the interalveolar septa were slightly thickened, presumably due to a proliferative response in the tissue, which is well documented in the literature. From Day 9 onwards, morphology of bilobectomized lungs did not differ from normal. At no instances we could detect clues for the formation of new alveoli. Several possible explanations for this structural recovery of the pulmonary parenchyma are discussed. Among these, a model is presented illustrating how the parenchymal morphology can be apparently normalized by the tissue proliferation, which renders the original widening of the airspaces unobtrusive on random sections through the respiratory tissue.
本研究描述了肺组织切除术后肺实质适应性反应的形态学变化。对23日龄大鼠进行右上叶和中叶双叶切除，切除的肺组织占肺总体积的25%。在术后第1、4、6、9、12、18和30天，通过标准化气管内灌注固定剂固定肺脏，通过水置换法测定肺体积，并制备左肺组织块用于扫描电子显微镜（SEM）观察。年龄匹配的正常动物和假手术动物作为对照。手术大鼠的肺体积迅速恢复到对照值。在扫描电子显微镜下，术后第1天，气腔增宽主要影响肺泡管，随后在第4天转移到肺泡水平，似乎是通过气腔增宽实现了体积增加。在第4天和第6天，肺泡间隔略有增厚，推测是由于组织中的增殖反应，这在文献中有充分记载。从第9天起，双叶切除肺的形态与正常肺无异。在任何情况下，我们都未检测到新肺泡形成的线索。本文讨论了肺实质这种结构恢复的几种可能解释。其中，提出了一个模型，说明肺实质形态如何通过组织增殖而明显恢复正常，这使得在通过呼吸组织的随机切片上，气腔最初的增宽不明显。
