Hsia C C, Herazo L F, Fryder-Doffey F, Weibel E R
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034.
J Clin Invest. 1994 Jul;94(1):405-12. doi: 10.1172/JCI117337.
We investigated the structural changes in the left lung of five adult male foxhounds 5 mo (n = 2) or 16 mo (n = 3) after right pneumonectomy (approximately 54% of lung resected) and five sex- and age-matched foxhounds 15-16 mo after right thoracotomy without pneumonectomy. Lungs were fixed by intratracheal instillation of glutaraldehyde and analyzed by standard morphometric techniques. After right pneumonectomy, volume of the left lung increased by 72%. Volumes of all septal structures increased significantly and were more pronounced at 5 than at 16 mo after pneumonectomy. At 16 mo, the relative increases in volume with respect to the control left lung were as follows: epithelium 73%, interstitium 100%, endothelium 55%, and capillary blood volume 43%. Surface areas of alveoli and capillary increased significantly by 52% and 34%, respectively. At 5 mo after pneumonectomy, harmonic mean thickness of the tissue-plasma barrier was significantly greater but at 16 mo it was not different from controls. There was a significant increase in diffusing capacity for oxygen (33% above controls) at 16 mo after pneumonectomy. These data suggest that, in contrast to previous findings after left pneumonectomy, compensatory lung growth does occur in adult dogs after resection of > 50% of lung.
我们研究了5只成年雄性猎狐犬在右肺切除术后（切除约54%的肺）5个月（n = 2）或16个月（n = 3）时左肺的结构变化，以及5只年龄和性别匹配的猎狐犬在进行右侧开胸但未进行肺切除术后15 - 16个月时左肺的结构变化。通过气管内滴注戊二醛固定肺组织，并采用标准形态计量学技术进行分析。右肺切除术后，左肺体积增加了72%。所有间隔结构的体积均显著增加，且在肺切除术后5个月时比16个月时更为明显。在16个月时，相对于对照左肺，各结构体积的相对增加如下：上皮73%、间质100%、内皮55%和毛细血管血容量43%。肺泡和毛细血管的表面积分别显著增加了52%和34%。肺切除术后5个月时，组织 - 血浆屏障的调和平均厚度显著更大，但在16个月时与对照组无差异。肺切除术后16个月时，氧扩散能力显著增加（比对照组高33%）。这些数据表明，与先前左肺切除术后的研究结果相反，成年犬在切除超过50%的肺后确实会发生代偿性肺生长。
