Collins J F
Exp Lung Res. 1982 Dec;4(1):29-36. doi: 10.3109/01902148209039247.
In order to study the accumulation of collagen during postnatal development in the major structures of the lung, trachea, bronchi, pulmonary vasculature, and parenchyma were isolated from the lungs of 1-week, 2-month, and 6-month-old rabbits. The concentrations of DNA, protein, and collagen in parenchyma were similar to those for whole lung. DNA per day weight for all structures declined with age. The DNA concentration of trachea at 6 months was only one-tenth that of parenchyma. Protein per dry weight was constant in parenchyma but dropped by half in trachea and nearly that in bronchi. Collagen per dry weight increased significantly between 1 week and 6 months in all structures. The collagen concentrations in vessels, bronchi, and trachea are similar to each other and three to five times that of parenchyma. The total amount of collagen in bronchi, trachea and parenchyma increased approximately 12-, 50-, and 90-fold, respectively, between 1 week and 6 months of age.
为了研究出生后肺主要结构发育过程中胶原蛋白的积累情况，从1周龄、2月龄和6月龄兔的肺中分离出气管、支气管、肺血管和实质。实质中DNA、蛋白质和胶原蛋白的浓度与全肺相似。所有结构的每单位湿重DNA随年龄下降。6月龄时气管的DNA浓度仅为实质的十分之一。实质中每单位干重蛋白质含量恒定，但气管中下降了一半，支气管中也几乎下降了一半。所有结构中每单位干重胶原蛋白在1周龄至6月龄之间显著增加。血管、支气管和气管中的胶原蛋白浓度彼此相似，是实质的三到五倍。支气管、气管和实质中的胶原蛋白总量在1周龄至6月龄之间分别增加了约12倍、50倍和90倍。
