Pagtakhan R D, Bjelland J C, Landau L I, Loughlin G, Kaltenborn W, Seeley G, Taussig L M
J Appl Physiol Respir Environ Exerc Physiol. 1984 May;56(5):1204-10. doi: 10.1152/jappl.1984.56.5.1204.
Seventeen boys and 19 girls, 8-15 yr in age, were studied to ascertain, in the two sex groups, the predictors of airway size [assessed by measurement of tracheal cross-sectional area (CSA) and maximal expiratory flows (Vmax)] and the relative rates of growth of the major divisions of the airways and lung parenchyma. In boys, total lung capacity (TLC) accounted for 77% of the variance of CSA and for 66% of the variability of Vmax. In contrast, somatic growth and maturation in girls accounted for only 45% of the variance of CSA and for 64% of the variability of Vmax; TLC was relatively unimportant. In boys, but not in girls, TLC-corrected CSA was significantly and inversely related to height and to TLC. In girls, TLC-corrected Vmax at 50 and 75% of forced vital capacity were directly related to height. These observations suggest different patterns of airway-parenchymal-somatic growth relationships in the two sexes. Furthermore, parenchymal growth appears to be the best determinant of airway growth in boys. In girls, other factors, perhaps genetic in nature, besides growth of parenchyma, may help determine airway size.
对17名男孩和19名年龄在8至15岁的女孩进行了研究，以确定在这两个性别组中，气道大小的预测因素（通过测量气管横截面积（CSA）和最大呼气流量（Vmax）来评估）以及气道和肺实质主要分支的相对生长速率。在男孩中，肺总量（TLC）占CSA变异的77%，占Vmax变异性的66%。相比之下，女孩的身体生长和成熟仅占CSA变异的45%，占Vmax变异性的64%；TLC相对不重要。在男孩中，而非女孩中，经TLC校正的CSA与身高和TLC呈显著负相关。在女孩中，用力肺活量50%和75%时经TLC校正的Vmax与身高呈正相关。这些观察结果表明两性在气道-实质-身体生长关系上存在不同模式。此外，实质生长似乎是男孩气道生长的最佳决定因素。在女孩中，除了实质生长外，其他因素（可能本质上是遗传因素）可能有助于决定气道大小。
