Radical scavengers and the stability of 99mTc-radiopharmaceuticals.
作者信息
Berger R
出版信息
Int J Appl Radiat Isot. 1982 Dec;33(12):1341-4. doi: 10.1016/0020-708x(82)90165-x.
PMID:7169269
Abstract
It was found that compounds, such as ene-1,2-diols, diphenyl derivatives, and certain oxidants, are suited to prevent decomposition of 99mTc-radiopharmaceuticals. For effective stabilization of 99mTc(Sn)-DTPA different radioactive concentrations of 99mTcO-4 solution require different concentrations of stabilizers. As a possible reason for the decomposition of 99mTc-radiopharmaceuticals radicals are discussed. Superoxide anion or hydroperoxyl radicals are especially taken into consideration.
摘要
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