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铬中毒大鼠的脂质蓄积

Lipid accumulation in chromium poisoned rats.

作者信息

Kumar A, Rana S V

出版信息

Int J Tissue React. 1982;4(4):291-5.

PMID:7169300
Abstract

Interference of chromium with the hepato-renal lipids in rat (Rattus rattus albino) was investigated using histochemical and biochemical parameters. Present results show that chromium stimulates the accumulation of triglycerides and phospholipids in both liver and kidney. Biochemical data on total lipids show that chromium enhanced the rate of lipid accumulations. Since lipids accumulate if the factors necessary for their utilization are missing, it is concluded that chromium manipulates an increase in the input of free fatty acids (FFA) causing triglyceride formation and inhibits mitochondrial phosphorylation. Inhibition of esterases has also been proposed as the reason for increased phospholipid accumulation.

摘要

利用组织化学和生化参数研究了铬对大鼠(白化大鼠)肝肾脂质的干扰作用。目前的结果表明,铬会刺激肝脏和肾脏中甘油三酯和磷脂的积累。总脂质的生化数据表明,铬提高了脂质积累的速率。由于如果缺少脂质利用所需的因素,脂质就会积累,因此得出结论,铬操纵游离脂肪酸(FFA)输入的增加,导致甘油三酯形成,并抑制线粒体磷酸化。酯酶的抑制也被认为是磷脂积累增加的原因。

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