Tokiwa T, Miyoshi K, Takahashi T, Uda F
Jpn J Antibiot. 1982 Nov;35(11):1620-8.
A subacute (5-week) subcutaneous toxicity study of cefsulodin (CFS) was carried out using 9 3-week old juvenile Beagle dogs. The dogs were distributed to 3 groups, each of which was constituted of 3 animals. Dogs in group I, II and III were given physiological saline (control), 300 mg/kg of cefazolin (CEZ, control drug) and 300 mg/kg of CFS, respectively. All animals used survived for 35 days of administration period. The changes, considered to be drug-related were histopathological changes at the sites of injection, which consisted inflammatory cellular infiltration and hyperplasia of fibroblast in subcutaneous tissue of skin. In terms of severity, CFS was less irritating than CEZ. CFS-related changes were not observed in other tests.
使用9只3周龄的幼年比格犬进行了头孢磺啶（CFS）的亚急性（5周）皮下毒性研究。将这些犬分为3组，每组由3只动物组成。第I组、第II组和第III组的犬分别给予生理盐水（对照）、300mg/kg的头孢唑林（CEZ，对照药物）和300mg/kg的CFS。所有使用的动物在给药期35天内均存活。被认为与药物相关的变化是注射部位的组织病理学变化，包括皮肤皮下组织中的炎性细胞浸润和成纤维细胞增生。在严重程度方面，CFS的刺激性小于CEZ。在其他试验中未观察到与CFS相关的变化。
