Muraoka Y, Nara H, Yoshizaki T, Harada Y
Jpn J Antibiot. 1982 Jan;35(1):222-39.
Chronic toxicity study of latamoxef (LMOX, 6059-S) by intravenous administration at dose levels of 100, 200 and 400 mg/kg daily for 6 months was carried out in adult Beagle dogs. All dogs of the 6059-S treated groups survived throughout the experimental period without showing any toxic signs other than occasional vomiting. Slight decrease of RBC, Ht, Hb and platelet, and increase of reticulocytes were noted in the 400 mg/kg group. Blood chemistry revealed decreased activity in GPT in the 6059-S treated groups, and increased contents of total protein and lipids in the 400 mg/kg group. These clinical changes were slight and transient in most instances. Liver and kidneys weights increased slightly without accompanying any pathological alterations. Inflammatory changes, probably due to mechanical irritation, were found in the subcutis and around the vein at the injection sites in all groups including the mannitol control group. From these results it is concluded that the maximum nontoxic dose in dogs is in the range of 200 to 400 mg/kg when the 6059-S was intravenously administered daily for 6 months.
对成年比格犬进行了拉氧头孢（LMOX，6059 - S）的慢性毒性研究，以每日100、200和400 mg/kg的剂量静脉给药，持续6个月。6059 - S治疗组的所有犬在整个实验期间均存活，除偶尔呕吐外未表现出任何毒性迹象。400 mg/kg组出现红细胞、血细胞比容、血红蛋白和血小板轻度下降，网织红细胞增加。血液生化显示6059 - S治疗组谷丙转氨酶活性降低，400 mg/kg组总蛋白和脂质含量增加。这些临床变化在大多数情况下轻微且短暂。肝脏和肾脏重量略有增加，未伴随任何病理改变。在包括甘露醇对照组在内的所有组的注射部位皮下和静脉周围发现了可能由于机械刺激引起的炎症变化。从这些结果得出结论，当6059 - S每日静脉给药6个月时，犬的最大无毒剂量在200至400 mg/kg范围内。
