Dequeker J, De Muylder E
Maturitas. 1982 Dec;4(4):309-13. doi: 10.1016/0378-5122(82)90063-9.
In view of the potential adverse consequences of oestrogen treatment, the effects of a progestogen on bone mass and bone remodelling have been evaluated in a longitudinal study. Bone mass and bone remodelling were measured radiogrammetrically in 39 peri-menopausal women who participated in an earlier cross-sectional study and continued to receive progestogen treatment, viz. lynestrenol, 5 mg daily, for 4.5 yr after the first assessment. Follow-up data obtained in untreated peri-menopausal and post-menopausal women and in oestrogen-treated post-menopausal women were used for comparison purposes. Pairs of hand films were measured blind by the same observer. For each pair of films, the average over six metacarpals of periosteal and endosteal width, cortical thickness and cortical area was calculated. In the progestogen-treated group a slight increase in periosteal diameter occurred, comparable to the untreated and oestrogen-treated groups. The increase in endosteal diameter in the progestogen-treated group is half that in the untreated groups, with a resultant smaller loss in cortical thickness in the lynestrenol group as compared with the untreated controls. Although lynestrenol's effectiveness in inhibiting bone resorption seems to be similar to that of oestrogen, the effect is less than that observed in post-menopausal women treated with conjugated equine oestrogens (1.25 mg) or ethinyl oestradiol (0.025 mg).
鉴于雌激素治疗可能产生的不良后果，在一项纵向研究中评估了一种孕激素对骨量和骨重塑的影响。对39名围绝经期妇女进行了骨量和骨重塑的放射测量，这些妇女参与了一项早期的横断面研究，并继续接受孕激素治疗，即在第一次评估后，每天服用5毫克炔诺醇，持续4.5年。未接受治疗的围绝经期和绝经后妇女以及接受雌激素治疗的绝经后妇女的随访数据用于比较。同一观察者对成对的手部X光片进行盲法测量。对于每对X光片，计算六个掌骨的骨膜和骨内膜宽度、皮质厚度和皮质面积的平均值。在孕激素治疗组中，骨膜直径略有增加，与未治疗组和雌激素治疗组相当。孕激素治疗组骨内膜直径的增加是未治疗组的一半，因此与未治疗的对照组相比，炔诺醇组皮质厚度的损失较小。虽然炔诺醇抑制骨吸收的效果似乎与雌激素相似，但其效果小于接受结合马雌激素（1.25毫克）或乙炔雌二醇（0.025毫克）治疗的绝经后妇女。
