Isaia G, Campagnoli C, Mussetta M, Massobrio M, Salamano G, Gallo M, Molinatti G M
Clinica Medica B, University of Turin, Italy.
Maturitas. 1989 Dec;11(4):287-94. doi: 10.1016/0378-5122(89)90025-x.
It now appears to be accepted that oestrogens and progestogens can help to prevent post-menopausal bone loss. This study accordingly evaluated vertebral bone mineral content (BMC) patterns and changes in calcitonin (CT) secretion in 12 women who had been ovariectomized in the previous 6 mth and in 12 others who had had a natural menopause, all of whom received oestrogen-progestogen replacement therapy for 12 mth. We also studied 12 oophorectomized and 21 normal-menopause women who did not receive any treatment and hence constituted the corresponding control groups. A significant difference was found between the lumbar BMC in the treated women and the controls. Moreover, the CT levels rose significantly after replacement therapy in both the oophorectomized and the natural-menopause subjects. It was concluded that combined oestrogen-progestogen treatment can prevent post-menopausal bone loss and increase CT secretion.
现在看来，雌激素和孕激素有助于预防绝经后骨质流失这一点已被认可。因此，本研究评估了12名在过去6个月内接受卵巢切除术的女性以及另外12名自然绝经女性的椎骨矿物质含量（BMC）模式和降钙素（CT）分泌变化，所有这些女性均接受了12个月的雌激素 - 孕激素替代疗法。我们还研究了12名接受卵巢切除术且未接受任何治疗的女性以及21名自然绝经女性，她们构成了相应的对照组。结果发现，接受治疗的女性与对照组的腰椎BMC存在显著差异。此外，在接受卵巢切除术的女性和自然绝经女性中，替代疗法后CT水平均显著升高。研究得出结论，雌激素 - 孕激素联合治疗可预防绝经后骨质流失并增加CT分泌。
