Holst J, Bäckström T, Hammarbäck S, von Schoultz B
Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden.
Maturitas. 1989 Mar;11(1):13-20. doi: 10.1016/0378-5122(89)90116-3.
Vasomotor symptoms and mood changes were followed in 2 groups of post-menopausal women receiving cyclic replacement therapy with 3 mg/day of percutaneous oestradiol-17 beta alone or in sequential combination (days 11-21) with lynestrenol 5 mg/day. During 6 mth of therapy, daily symptom ratings were performed using a visual analogue scale technique. Serum levels of oestradiol were similar in both groups but sequential oestrogen/progestogen treatment was more efficient in suppressing vasomotor symptoms and serum gonadotropins. However, all negative mood symptoms were also more pronounced in this group. Progestogen addition may enhance the therapeutic effect on hot flushes and sweats but, at least in individual women cause unfavourable effects on mental status, mood and well-being.
对两组接受绝经后激素替代治疗的妇女进行血管舒缩症状和情绪变化的跟踪研究。一组妇女每天经皮给予3毫克17β-雌二醇，另一组妇女每天经皮给予3毫克17β-雌二醇，并在第11至21天序贯联合给予5毫克炔诺醇。在6个月的治疗期间，使用视觉模拟量表技术对症状进行每日评分。两组的雌二醇血清水平相似，但序贯雌激素/孕激素治疗在抑制血管舒缩症状和血清促性腺激素方面更有效。然而，该组中所有负面情绪症状也更明显。添加孕激素可能会增强对潮热和盗汗的治疗效果，但至少在个别女性中会对精神状态、情绪和幸福感产生不利影响。
