Goto N, Akama K
Microbiol Immunol. 1982;26(12):1121-32. doi: 10.1111/j.1348-0421.1982.tb00261.x.
Histopathological observations of changes at the injection site in mice were made for 20 weeks after a single intramuscular (im) injection of aluminum hydroxide-adsorbed tetanus toxoid (Alum-TT), plain tetanus toxoid (TT), or aluminum adjuvant (Alum alone). Marked injury to muscle fibers and infiltration of neutrophils around the aluminum remnants were observed, and some microabscesses were occasionally formed, after im injection of Alum-TT. Some mature alum-granulomas were seen in the Alum-TT group, while the Alum alone group had only a few immature alum-granulomas. The TT group showed only slight injury to muscle fibers and acute inflammation at an early stage. In the Alum-TT group, well-developed lymphold tissues and granulomatous lesions were still observable even 20 weeks after the injection; however, these changes had already diminished in the Alum alone group by that time. These findings could serve as good models for undesirable local reactions to aluminum-adjuvanted vaccines.
在小鼠单次肌肉注射氢氧化铝吸附破伤风类毒素（Alum-TT）、普通破伤风类毒素（TT）或铝佐剂（仅铝佐剂）后，对注射部位的变化进行了20周的组织病理学观察。肌肉注射Alum-TT后，观察到肌肉纤维有明显损伤，铝残留物周围有中性粒细胞浸润，偶尔会形成一些微脓肿。在Alum-TT组可见一些成熟的铝肉芽肿，而仅铝佐剂组只有少数未成熟的铝肉芽肿。TT组仅在早期显示肌肉纤维有轻微损伤和急性炎症。在Alum-TT组，即使在注射后20周仍可观察到发育良好的淋巴组织和肉芽肿性病变；然而，到那时仅铝佐剂组的这些变化已经减轻。这些发现可作为铝佐剂疫苗不良局部反应的良好模型。
