Loewenstein R J, Weingartner H, Gillin J C, Kaye W, Ebert M, Mendelson W B
Neurobiol Aging. 1982 Winter;3(4):371-7. doi: 10.1016/0197-4580(82)90025-2.
The relationship of sleep, circadian rhythms, and cognitive impairment in dementia patients is briefly reviewed. All-night sleep EEG data were collected in relatively young and relatively unimpaired patients with presumptive Alzheimer's disease and eight age-matched controls. Delta sleep time and Delta sleep % (Stages 3 and 4)--but not REM sleep measures--were significantly reduced in the patients. Implications of these findings are discussed.
本文简要回顾了痴呆症患者的睡眠、昼夜节律与认知障碍之间的关系。研究收集了相对年轻且认知功能相对未受损的疑似阿尔茨海默病患者以及八名年龄匹配的对照者的整夜睡眠脑电图数据。结果显示，患者的慢波睡眠时间和慢波睡眠百分比（3期和4期）显著降低，但快速眼动睡眠指标无明显变化。本文还讨论了这些研究结果的意义。
