Prinz P N, Vitaliano P P, Vitiello M V, Bokan J, Raskind M, Peskind E, Gerber C
Neurobiol Aging. 1982 Winter;3(4):361-70. doi: 10.1016/0197-4580(82)90024-0.
Sleep, EEG and mental function variables were studied in 44 subjects diagnosed as having probable senile dementia of the Alzheimer's type (SDAT) and 22 controls matched for age and minimal depression. Results indicate that sleep, EEG and mental function variables all undergo significant change even in the early, mild stage of SDAT, with further change in the moderate and severe stages of dementia. Mental function variables also underwent significant decline across levels of dementia. Sleep and mental function variables had strong power in correctly classifying subjects into control vs. mild dementia groups (90 and 100%, respectively). Dominant occipital rhythm frequency, a clinical EEG measure, also discriminate as well (75%). The results indicate that sleep and EEG variables discriminate well for early, mild SDAT in minimally depressed aged individuals.
对44名被诊断患有可能的阿尔茨海默病型老年痴呆症（SDAT）的受试者以及22名年龄匹配且抑郁程度最低的对照组进行了睡眠、脑电图和心理功能变量的研究。结果表明，即使在SDAT的早期轻度阶段，睡眠、脑电图和心理功能变量都会发生显著变化，在痴呆症的中度和重度阶段会有进一步变化。心理功能变量在不同痴呆程度之间也有显著下降。睡眠和心理功能变量在将受试者正确分类为对照组与轻度痴呆组方面具有很强的能力（分别为90%和100%）。作为一种临床脑电图测量指标的枕叶优势节律频率也有较好的区分能力（75%）。结果表明，睡眠和脑电图变量在轻度抑郁的老年个体中对早期轻度SDAT有很好的区分作用。
