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一名年轻女性酗酒者因“微小病变”肝病导致肝脏肿大。

Gross hepatomegaly due to 'minimal change' liver disease in a young female alcoholic.

作者信息

Majumdar S K, Thomson A D, Shaw G K, O'Gorman P, Aps E J, Bugler J

出版信息

Postgrad Med J. 1982 Dec;58(686):799-802. doi: 10.1136/pgmj.58.686.799.

DOI:10.1136/pgmj.58.686.799
PMID:7170293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2426601/
Abstract

The case of a grossly enlarged liver due to alcohol excess in a woman of 21 is reported. This case further demonstrates that a chronic alcoholic can have gross hepatomegaly with normal histology and normal liver function tests. The possible pathogenetic basis of ethanol-induced hepatomegaly (‘minimal change’ liver disease) is discussed.

摘要

报告了一例21岁女性因饮酒过量导致肝脏显著肿大的病例。该病例进一步证明，慢性酗酒者可出现肝脏显著肿大，但组织学正常且肝功能检查正常。文中讨论了乙醇诱导肝肿大（“微小病变”肝病）可能的发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df3/2426601/a7f277a6df63/postmedj00216-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df3/2426601/d15657faec92/postmedj00216-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df3/2426601/4dfd676f862b/postmedj00216-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df3/2426601/a7f277a6df63/postmedj00216-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df3/2426601/d15657faec92/postmedj00216-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df3/2426601/4dfd676f862b/postmedj00216-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df3/2426601/a7f277a6df63/postmedj00216-0071-a.jpg

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本文引用的文献

1
Do women develop alcoholic liver disease more readily than men?女性比男性更容易患酒精性肝病吗？
Br Med J (Clin Res Ed). 1981 Apr 4;282(6270):1140-3. doi: 10.1136/bmj.282.6270.1140.
2
Indocyanine green clearance as a test for hepatic function. Evaluation by dichromatic ear densitometry.吲哚菁绿清除率作为肝功能检测方法。双色耳密度测定法评估。
JAMA. 1967 Apr 17;200(3):236-40.
3
Experimental alcoholic hepatic injury in man: ultrastructural changes.
Fed Proc. 1967 Sep;26(5):1458-67.
4
Giant mitochondria in hepatocytes: a diagnostic hint for alcoholic liver disease.肝细胞中的巨大线粒体：酒精性肝病的诊断线索。
Gastroenterology. 1977 Dec;73(6):1383-7.
5
Alcoholic liver disease.酒精性肝病
Br J Hosp Med. 1977 Aug;18(2):118-20.