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三碘甲状腺原氨酸在甲状腺功能亢进和减退时基础代谢率调节中的优先作用。

The preferential role of triiodothyronine in the regulation of basal metabolic rate in hyper- and hypothyroidism.

作者信息

Johansen K, Hansen J M, Skovsted L

出版信息

Acta Med Scand. 1978;204(5):357-9. doi: 10.1111/j.0954-6820.1978.tb08454.x.

DOI:10.1111/j.0954-6820.1978.tb08454.x
PMID:717056
Abstract

The free triiodothyronine index (FT3I) was significantly correlated to basal metabolic rate (BMR) in hyperthyroid (r=+0.63, p less than 0.01) and hypothyroid patients (r=+0.61, p less than 0.05). Elimination of the effect of the free thyroxine index (FT4I) on the total correlation between BMR and FT3I by partial correlation analysis gave partial r=+0.60, p less than 0.01 in hyperthyroid patients and partial r=+0.43, p less than 0.1 in hypothyroid patients. The FT4I did not correlate to BMR in either hyper- or hypothyroid patients. These results point to triiodothyronine as the major regulator of BMR in hyper- and hypothyroidism.

摘要

在甲状腺功能亢进患者中,游离三碘甲状腺原氨酸指数(FT3I)与基础代谢率(BMR)显著相关(r = +0.63,p < 0.01);在甲状腺功能减退患者中,二者也显著相关(r = +0.61,p < 0.05)。通过偏相关分析消除游离甲状腺素指数(FT4I)对BMR与FT3I之间总相关性的影响后,在甲状腺功能亢进患者中得到的偏相关系数r = +0.60,p < 0.01;在甲状腺功能减退患者中,偏相关系数r = +0.43,p < 0.1。在甲状腺功能亢进或减退患者中,FT4I与BMR均无相关性。这些结果表明,在甲状腺功能亢进和减退状态下,三碘甲状腺原氨酸是BMR的主要调节因子。

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