毒草安（2-氯-N-异丙基乙酰苯胺）的硫醚氨酸途径代谢物的快原子轰击质谱

Fast atom bombardment mass spectra of mercapturic acid-pathway metabolites of propachlor (2-chloro-N-isopropylacetanilide).

Larsen G L, Ryhage R

Xenobiotica. 1982 Dec;12(12):855-60. doi: 10.3109/00498258209038957.

Abstract

Fast atom bombardment (FAB) mass spectra, obtained from mercapturic acid-pathway metabolites (glutathione-, mercapturic acid- and cysteine-conjugates, and a sulphoxide of the mercapturate) of propachlor, are presented. 2. Each underivatized mercapturic acid-pathway metabolite of propachlor gave a FAB mass spectrum containing an (M + H)+ ion (7-100% relative intensity), an (M + Na)+ ion and characteristic fragment ions. 3. The advantage of the FAB technique in obtaining mass spectra of these mercapturic acid-pathway metabolites of propachlor and other xenobiotics is discussed. 4. Ions in the FAB spectra resulting from sample fragment/glycerol interactions were characterized.

摘要

给出了从毒草胺的硫醚氨酸途径代谢物（谷胱甘肽、硫醚氨酸和半胱氨酸结合物，以及硫醚氨酸的亚砜）获得的快原子轰击（FAB）质谱。2. 毒草胺的每种未衍生化硫醚氨酸途径代谢物都给出了一个FAB质谱，其中包含一个（M + H）⁺离子（相对强度为7 - 100%）、一个（M + Na）⁺离子和特征性碎片离子。3. 讨论了FAB技术在获得毒草胺和其他异生物质的这些硫醚氨酸途径代谢物质谱方面的优势。4. 对FAB谱中由样品碎片/甘油相互作用产生的离子进行了表征。