在毒草胺（2-氯-N-异丙基乙酰苯胺）代谢过程中，氯被甲磺酰基取代。

Replacement of a chlorine with a methylsulfonyl group in the metabolism of propachlor (2-chloro-N-isopropylacetanilide).

作者信息

Bakke J E, Feil V J, Price C E

出版信息

Biomed Mass Spectrom. 1976 Oct;3(5):226-9. doi: 10.1002/bms.1200030506.

DOI:10.1002/bms.1200030506

Abstract

Urine from rats and sheep given single doses of [14C]propachlor contained 14C metabolites in which the chlorine of propachlor was replaced by a methylsulfonyl group. Methylsulfonyl-containing metabolites were also isolated from the urine of rats given an intraperitoneal dose of the cysteine conjugate of [14C]propachlor; this indicated that the methylsulfonyl-containing metabolites resulted from metabolic reactions subsequent to the mercapturic acid pathway.

摘要

给大鼠和绵羊单次注射[14C]扑草净后，其尿液中含有14C代谢物，其中扑草净的氯原子被甲磺酰基取代。从腹腔注射[14C]扑草净半胱氨酸共轭物的大鼠尿液中也分离出了含甲磺酰基的代谢物；这表明含甲磺酰基的代谢物是在巯基尿酸途径之后的代谢反应产生的。