Kawano S I, Honda Y, Negi A
Acta Ophthalmol (Copenh). 1982 Dec;60(6):977-91. doi: 10.1111/j.1755-3768.1982.tb00630.x.
Changes in the physical properties of the vitreous induced by various biological stimuli were investigated with Cannon-Fenske kinematic and cone-plate rotary viscometers. Heating greatly decreased the viscosity of the human vitreous, the critical temperature being between 50 degrees C and 60 degrees C. Freezing also affected the viscosity, but less so than heating. Viscosity of hyaluronic acid was also decreased by heating to approximately 60 degrees C. Preliminary incubation with hyaluronidase made the viscosity of both the vitreous and hyaluronic acid heat-stable. Lens extraction decreased vitreous viscosity markedly, suggesting a decrease of hyaluronic acid concentration and/or a lowering of hyaluronic acid molecular weight. Vitreous haemorrhage resulted in decreased vitreous viscosity. Cryoretinopexy at the level employed in this study induced little change in vitreous viscosity, while retinal diathermy caused a moderate decrease. In the course of vitreous haemorrhage and retinal diathermy, a return towards normal of the viscosity was observed, suggesting the presence of local hyaluronic acid production.
使用坎农-芬斯克运动粘度计和锥板旋转粘度计研究了各种生物刺激引起的玻璃体物理性质变化。加热会大大降低人玻璃体的粘度，临界温度在50摄氏度至60摄氏度之间。冷冻也会影响粘度，但影响程度小于加热。加热至约60摄氏度时，透明质酸的粘度也会降低。用透明质酸酶进行初步孵育可使玻璃体和透明质酸的粘度都具有热稳定性。晶状体摘除显著降低了玻璃体粘度，这表明透明质酸浓度降低和/或透明质酸分子量降低。玻璃体出血导致玻璃体粘度降低。本研究中采用的冷冻视网膜固定术对玻璃体粘度几乎没有影响，而视网膜透热疗法则导致适度降低。在玻璃体出血和视网膜透热疗法过程中，观察到粘度恢复正常，这表明存在局部透明质酸产生。
