利血平对大鼠睾丸间质细胞影响的组织形态计量学分析
Histometric analysis of the effects of reserpine on the interstitial cells of the rat testis.
作者信息
Dias P L
出版信息
Br J Exp Pathol. 1982 Oct;63(5):518-21.
Abstract
Reserpine is known to block luteinizing hormone (LH) release and by this action to inhibit ovulation, delay implantation and cause abortion in rats. A histometric technique was applied to estimate quantitatively the changes in the density of rat testis interstitial cells after the injection of a fixed dose of reserpine over a varying period of time. A significant decrease in the density of the interstitial cell population was observed in relation to the duration of treatment with reserpine. Reserpine appears to produce atrophy of the interstitial cells of the testis possibly due to its LH-inhibiting action.
摘要
利血平已知可阻断促黄体生成素（LH）释放，并通过此作用抑制大鼠排卵、延迟着床及导致流产。应用一种组织计量学技术来定量估计在不同时间段注射固定剂量利血平后大鼠睾丸间质细胞密度的变化。观察到间质细胞群体密度相对于利血平治疗持续时间有显著下降。利血平似乎可能因其抑制LH的作用而导致睾丸间质细胞萎缩。
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